The Anatomy of Melancholy, 148: The four humours, melancholy

Melancholy, cold and dry, thick, black, sour, begotten of the more feculent part of nourishment, and purged from the spleen, is a bridle to the other two hot humours, blood and choler, preserving them in the blood, and nourishing the bones. These four humours have some analogy with the four elements, and to the four ages of man.